2-1-1 PrEP: How It Is Used and Who It Is For

2-1-1 PrEP uses oral TDF/FTC before and after sex on a defined schedule. Evidence is limited to adult cisgender men who have sex with men and can plan sex in advance. It is off-label, and CDC does not recommend it as a routine general regimen. Discuss it with a provider and follow local guidance.

The 2-1-1 Schedule

1. Take two TDF/FTC tablets 2–24 hours before sex.
2. Take one tablet 24 hours after the first dose.
3. Take one tablet 48 hours after the first dose.

For sex on consecutive days, dosing continues daily and after the final exposure according to guidance. Ask rather than improvising.

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Who Should Not Use 2-1-1?

It is not for vaginal or frontal exposure, people who inject drugs, people unable to plan sex, people with HIV, or people with active hepatitis B without clinical supervision. Intermittently starting and stopping TDF/FTC can affect hepatitis B. The schedule does not apply to injectable PrEP or other oral products.

Before Starting

HIV testing and assessment for acute symptoms are required, with kidney and hepatitis B checks when indicated. After an exposure within 72 hours, seek PEP; do not try to use 2-1-1 retrospectively.

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What PrEP Does Not Prevent

PrEP does not prevent gonorrhea, chlamydia, syphilis, or other STIs. Consider condoms or dental dams and screening based on exposure.

Verified references

Links and relevance to the article’s main topic were reviewed on 13 August 2026. Each source supports only the scope stated in the original document and does not replace personalised medical, legal, or service advice.

1. CDC: Clinical Guidance for PrEP Accessed 13 August 2026
2. WHO: HIV and AIDS fact sheet Accessed 13 August 2026