{"id":19311,"date":"2022-05-08T09:00:00","date_gmt":"2022-05-08T02:00:00","guid":{"rendered":"https:\/\/lovefoundation.or.th\/?p=19311"},"modified":"2025-10-24T17:52:33","modified_gmt":"2025-10-24T10:52:33","slug":"prep-vs-pep","status":"publish","type":"post","link":"https:\/\/lovefoundation.or.th\/en\/prep-vs-pep\/","title":{"rendered":"PrEP vs PEP &#8211; What\u2019s the Difference and Why It Matters"},"content":{"rendered":"<p>Many people have probably heard about medications used to prevent <span style=\"color: #3366ff;\"><a style=\"color: #3366ff;\" href=\"https:\/\/lovefoundation.or.th\/en\/about-hiv\/\">HIV infection<\/a><\/span>, such as <strong data-start=\"235\" data-end=\"243\">PrEP<\/strong> and <strong data-start=\"248\" data-end=\"255\">PEP<\/strong>. However, there are still many misunderstandings about how these medicines work. Some people take the wrong type, use them incorrectly, or believe they can simply buy PrEP or PEP over the counter at any pharmacy. In reality, these HIV prevention drugs <strong data-start=\"508\" data-end=\"542\">must be prescribed by a doctor<\/strong> after consultation and blood testing. They are considered <strong data-start=\"601\" data-end=\"638\">specialized antiviral medications<\/strong>, and can only be taken <strong data-start=\"662\" data-end=\"689\">if you are HIV-negative<\/strong> at the time of screening.<\/p>\n\n\t<section class=\"section round-corners\" id=\"section_1409681092\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\t<div class=\"is-border\"\n\t\tstyle=\"border-radius:10px;border-width:1px 1px 1px 1px;\">\n\t<\/div>\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\t<div id=\"text-1870821017\" class=\"text\">\n\t\t\n<h2>List of Contents<\/h2>\n\t\t\n<style>\n#text-1870821017 {\n  font-size: 1.1rem;\n}\n@media (min-width:550px) {\n  #text-1870821017 {\n    font-size: 1rem;\n  }\n}\n<\/style>\n\t<\/div>\n\t\n<ol>\n<li><a href=\"#1\">What is PrEP?<\/a><\/li>\n<li data-start=\"769\" data-end=\"783\"><a href=\"#2\">What is PEP?<\/a><\/li>\n<li data-start=\"786\" data-end=\"819\"><a href=\"#3\">How are PrEP and PEP different?<\/a><\/li>\n<li data-start=\"822\" data-end=\"851\"><a href=\"#4\">Who should use PrEP or PEP?<\/a><\/li>\n<li data-start=\"854\" data-end=\"890\"><a href=\"#5\">How to take PrEP and PEP correctly<\/a><\/li>\n<li data-start=\"893\" data-end=\"930\"><a href=\"#6\">Do PrEP and PEP really prevent HIV?<\/a><\/li>\n<li data-start=\"933\" data-end=\"972\"><a href=\"#7\">Possible side effects of PrEP and PEP<\/a><\/li>\n<\/ol>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1409681092 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n  background-color: rgb(248, 247, 245);\n}\n<\/style>\n\t<\/section>\n\t\n\t<div id=\"gap-555355635\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-555355635 {\n  padding-top: 30px;\n}\n<\/style>\n\t<\/div>\n\t\n<span class=\"scroll-to\" data-label=\"Scroll to: #1\" data-bullet=\"false\" data-link=\"#1\" data-title=\"1\"><a name=\"1\"><\/a><\/span>\n<h2 data-start=\"979\" data-end=\"1002\">What is PrEP?<\/h2>\n<p data-start=\"1003\" data-end=\"1258\">PrEP (Pre-Exposure Prophylaxis) is a medication used to prevent HIV infection <strong data-start=\"1081\" data-end=\"1091\">before<\/strong> potential exposure \u2014 in simple terms, before having sex. When taken consistently in sufficient amounts, PrEP helps block the virus from multiplying inside the body.<\/p>\n<p data-start=\"1260\" data-end=\"1397\">Before starting PrEP, you must consult a doctor and undergo several health checks to ensure you\u2019re ready for the medication, including:<\/p>\n<ul>\n<li data-start=\"1400\" data-end=\"1413\">HIV testing<\/li>\n<li data-start=\"1416\" data-end=\"1438\">Liver function tests<\/li>\n<li data-start=\"1441\" data-end=\"1464\">Kidney function tests<\/li>\n<li data-start=\"1467\" data-end=\"1490\">Hepatitis B screening<\/li>\n<li data-start=\"1493\" data-end=\"1506\">STIs testing<\/li>\n<li data-start=\"1509\" data-end=\"1537\">Pregnancy test (for women)<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-19320\" src=\"https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PrEP.jpg\" alt=\"What is PrEP\" width=\"1000\" height=\"667\" srcset=\"https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PrEP.jpg 1000w, https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PrEP-300x200.jpg 300w, https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PrEP-768x512.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<span class=\"scroll-to\" data-label=\"Scroll to: #2\" data-bullet=\"false\" data-link=\"#2\" data-title=\"2\"><a name=\"2\"><\/a><\/span>\n<h2 data-start=\"1544\" data-end=\"1566\">What is PEP?<\/h2>\n<p data-start=\"1567\" data-end=\"1887\">PEP (Post-Exposure Prophylaxis) is a medication taken <strong data-start=\"1621\" data-end=\"1630\">after<\/strong> potential exposure to HIV \u2014 for instance, after having sex with someone who might be HIV-positive. PEP works by stopping the virus from replicating and becoming established in the body, allowing your immune system to eliminate it before infection occurs.<\/p>\n<p data-start=\"1889\" data-end=\"2007\">Before prescribing PEP, a doctor will assess your risk and confirm you don\u2019t already have HIV. Common tests include:<\/p>\n<ul>\n<li data-start=\"2010\" data-end=\"2023\">HIV testing<\/li>\n<li data-start=\"2026\" data-end=\"2053\">Liver function (AST, ALT)<\/li>\n<li data-start=\"2056\" data-end=\"2083\">Kidney function (BUN, Cr)<\/li>\n<li data-start=\"2086\" data-end=\"2123\">Hepatitis B surface antigen (HBsAg)<\/li>\n<li data-start=\"2126\" data-end=\"2161\">Hepatitis B antibody (Anti-HBsAg)<\/li>\n<li data-start=\"2164\" data-end=\"2197\">Hepatitis C antibody (Anti-HCV)<\/li>\n<li data-start=\"2200\" data-end=\"2215\">STIs screening<\/li>\n<li data-start=\"2218\" data-end=\"2246\">Pregnancy test (for women)<\/li>\n<\/ul>\n<blockquote>\n<p style=\"text-align: center;\"><span style=\"font-size: 110%; color: #ff6600;\">\u201cPrEP is taken before risk; PEP is taken after exposure in an emergency.\u201d<\/span><\/p>\n<\/blockquote>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-19318\" src=\"https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PEP.jpg\" alt=\"What is PEP\" width=\"1000\" height=\"667\" srcset=\"https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PEP.jpg 1000w, https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PEP-300x200.jpg 300w, https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/What-is-PEP-768x512.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<span class=\"scroll-to\" data-label=\"Scroll to: #3\" data-bullet=\"false\" data-link=\"#3\" data-title=\"3\"><a name=\"3\"><\/a><\/span>\n<h2 data-start=\"2335\" data-end=\"2376\">How are PrEP vs PEP different?<\/h2>\n<p data-start=\"2377\" data-end=\"2764\">In short, <strong data-start=\"2387\" data-end=\"2433\">PrEP is used before potential HIV exposure<\/strong>, while <strong data-start=\"2441\" data-end=\"2471\">PEP is used after exposure<\/strong>. If you\u2019re unsure which one is right for you, it\u2019s always best to consult a doctor. Using the wrong medication or taking it incorrectly may reduce its effectiveness and put your health at risk. Doctors will determine the most appropriate option based on your risk level and sexual behavior.<\/p>\n<span class=\"scroll-to\" data-label=\"Scroll to: #4\" data-bullet=\"false\" data-link=\"#4\" data-title=\"4\"><a name=\"4\"><\/a><\/span>\n<h2>Who should use PrEP vs PEP ?<\/h2>\n<table>\n<thead>\n<tr>\n<th>PrEP is suitable for<\/th>\n<th>PEP is suitable for<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>People who frequently have sex without condoms<\/td>\n<td>Those who had sex without a condom<\/td>\n<\/tr>\n<tr>\n<td>Men who have sex with men<\/td>\n<td>Condom breakage or slippage<\/td>\n<\/tr>\n<tr>\n<td>People with multiple partners or serodiscordant relationships<\/td>\n<td>Victims of sexual assault<\/td>\n<\/tr>\n<tr>\n<td>People who inject drugs<\/td>\n<td>Those who shared injection equipment<\/td>\n<\/tr>\n<tr>\n<td>People diagnosed with an STI within the past 6 months<\/td>\n<td>Those who had unprotected sex while intoxicated<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<span class=\"scroll-to\" data-label=\"Scroll to: #5\" data-bullet=\"false\" data-link=\"#5\" data-title=\"5\"><a name=\"5\"><\/a><\/span>\n<h2 data-start=\"3324\" data-end=\"3356\">How to Take PrEP vs PEP<\/h2>\n<p data-start=\"3358\" data-end=\"3752\"><span style=\"text-decoration: underline;\"><span style=\"font-size: 110%;\">PrEP (Before Exposure)<\/span><\/span><\/p>\n<p data-start=\"3358\" data-end=\"3752\">Take one pill daily at the same time. It should be taken for at least <strong data-start=\"3457\" data-end=\"3493\">7 days before potential exposure<\/strong> and continued <strong data-start=\"3508\" data-end=\"3534\">for 3 months or longer<\/strong> as prescribed. If you miss a dose, take it as soon as you remember \u2014 but never double up. When stopping PrEP, continue for <strong data-start=\"3660\" data-end=\"3703\">4 weeks after the last sexual encounter<\/strong>, and consult your doctor before discontinuing.<\/p>\n<p data-start=\"3358\" data-end=\"3752\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-19314\" src=\"https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/How-are-PrEP-vs-PEP-different.jpg\" alt=\"How are PrEP vs PEP different\" width=\"1000\" height=\"667\" srcset=\"https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/How-are-PrEP-vs-PEP-different.jpg 1000w, https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/How-are-PrEP-vs-PEP-different-300x200.jpg 300w, https:\/\/lovefoundation.or.th\/wp-content\/uploads\/2022\/05\/How-are-PrEP-vs-PEP-different-768x512.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<p data-start=\"3754\" data-end=\"4122\"><span style=\"text-decoration: underline;\"><span style=\"font-size: 110%;\">PEP (After Exposure)<\/span><\/span><\/p>\n<p data-start=\"3754\" data-end=\"4122\">PEP should be started <strong data-start=\"3803\" data-end=\"3859\">as soon as possible \u2014 within 72 hours after exposure<\/strong>. The treatment lasts <strong data-start=\"3881\" data-end=\"3892\">28 days<\/strong>, and it\u2019s crucial to complete the full course without missing doses. After finishing, return for follow-up HIV testing immediately and again <strong data-start=\"4034\" data-end=\"4052\">after 3 months<\/strong>. During this period, avoid donating blood and always use condoms.<\/p>\n<span class=\"scroll-to\" data-label=\"Scroll to: #6\" data-bullet=\"false\" data-link=\"#6\" data-title=\"6\"><a name=\"6\"><\/a><\/span>\n<h2 data-start=\"4129\" data-end=\"4172\">Do PrEP and PEP Really Prevent HIV?<\/h2>\n<p data-start=\"4174\" data-end=\"4386\">Both PrEP and PEP are highly effective in preventing HIV infection \u2014 <strong data-start=\"4243\" data-end=\"4280\">PrEP reduces the risk by over 90%<\/strong> when taken correctly, while <strong data-start=\"4309\" data-end=\"4343\">PEP reduces the risk by 70\u201380%<\/strong> if started promptly and completed fully. However, <strong data-start=\"4397\" data-end=\"4436\">neither protects against other STIs<\/strong> such as gonorrhea, syphilis, or herpes. That\u2019s why combining these medications with <strong data-start=\"4521\" data-end=\"4535\">condom use<\/strong> remains the best strategy for full protection. People taking PrEP should visit their doctor <strong data-start=\"4631\" data-end=\"4651\">every 3\u20136 months<\/strong> for HIV testing and health monitoring. Consistent follow-up ensures continued effectiveness and early detection of any side effects or health issues.\u00a0PEP, meanwhile, is meant for emergencies only \u2014 if you find yourself at frequent risk, switching to regular PrEP is more suitable.<\/p>\n<span class=\"scroll-to\" data-label=\"Scroll to: #7\" data-bullet=\"false\" data-link=\"#7\" data-title=\"7\"><a name=\"7\"><\/a><\/span>\n<h2 data-start=\"4944\" data-end=\"4989\">Possible Side Effects of PrEP and PEP<\/h2>\n<p data-start=\"4991\" data-end=\"5233\">Both PrEP and PEP may cause <strong data-start=\"5019\" data-end=\"5051\">mild, temporary side effects<\/strong> during the first 1\u20132 weeks, such as headache, nausea, vomiting, or loss of appetite. These usually go away on their own. If symptoms persist beyond two weeks, consult your doctor.\u00a0When taken correctly under medical supervision, PrEP and PEP are <strong data-start=\"5300\" data-end=\"5322\">safe and effective<\/strong> tools that can significantly reduce the risk of HIV infection and transmission.<\/p>\n\n\t<section class=\"section round-corners\" id=\"section_1894672575\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\t<div class=\"is-border\"\n\t\tstyle=\"border-radius:10px;border-width:1px 1px 1px 1px;\">\n\t<\/div>\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n<p><span style=\"font-size: 120%;\"><strong>Related Article<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #3366ff;\"><a style=\"color: #3366ff;\" href=\"https:\/\/lovefoundation.or.th\/en\/pep-explained\/\">PEP Explained \u2013 What It Really Is and How It Works?<\/a><\/span><\/li>\n<li><span style=\"color: #3366ff;\"><a style=\"color: #3366ff;\" href=\"https:\/\/lovefoundation.or.th\/en\/prep-and-hiv-prevention\/\">PrEP and HIV Prevention : A Comprehensive Guide<\/a><\/span><\/li>\n<\/ul>\n\t\t<\/div>\n\n\t\t\n<style>\n#section_1894672575 {\n  padding-top: 30px;\n  padding-bottom: 30px;\n  background-color: rgb(248, 247, 245);\n}\n<\/style>\n\t<\/section>\n\t\n<p data-start=\"5556\" data-end=\"5574\"><span style=\"font-size: 120%;\"><strong data-start=\"5560\" data-end=\"5574\">Conclusion<\/strong><\/span><\/p>\n<p data-start=\"5576\" data-end=\"5902\"><strong data-start=\"5576\" data-end=\"5633\">PrEP and PEP are vital tools in modern HIV prevention<\/strong>, empowering individuals to take charge of their own health with confidence. The most important thing is <strong data-start=\"5738\" data-end=\"5788\">using them correctly under medical supervision<\/strong> \u2014 each has a specific purpose and timing. Using the wrong one or skipping doses may reduce their effectiveness.\u00a0The best HIV prevention comes from a <strong data-start=\"5941\" data-end=\"5967\">combination of methods<\/strong>: appropriate use of PrEP or PEP, consistent condom use, regular sexual-health checkups, and open communication with your doctor or partner. Being informed and proactive not only protects your health but also helps build a safer, more understanding society for everyone.<\/p>\n\t<div id=\"gap-920108589\" class=\"gap-element clearfix\" style=\"display:block; height:auto;\">\n\t\t\n<style>\n#gap-920108589 {\n  padding-top: 100px;\n}\n<\/style>\n\t<\/div>\n\t\n<p><span style=\"font-size: 115%;\"><strong>References:<\/strong><\/span><\/p>\n<p>\u21aa\ufe0e <a href=\"https:\/\/www.phyathai.com\/th\/article\/prep-and-pep?srsltid=AfmBOop1kr3RzEWn_ciCsWSutDlhxAGvJNLeYmyCVSXokuI1nWffUzR1\">\u0e23\u0e39\u0e49\u0e44\u0e27\u0e49! \u0e43\u0e0a\u0e49 PrEP &amp; PEP \u0e2d\u0e22\u0e48\u0e32\u0e07\u0e16\u0e39\u0e01\u0e27\u0e34\u0e18\u0e35 \u0e0a\u0e48\u0e27\u0e22\u0e25\u0e14\u0e04\u0e27\u0e32\u0e21\u0e40\u0e2a\u0e35\u0e48\u0e22\u0e07\u0e15\u0e34\u0e14\u0e40\u0e0a\u0e37\u0e49\u0e2d HIV<\/a><\/p>\n<p>\u21aa\ufe0e <a href=\"https:\/\/th.aidsid.or.th\/cotrcarc241123\/\">\u0e21\u0e32\u0e17\u0e33\u0e04\u0e27\u0e32\u0e21\u0e23\u0e39\u0e49\u0e08\u0e31\u0e01\u0e01\u0e31\u0e1a\u0e22\u0e32 PrEP (\u0e40\u0e1e\u0e23\u0e47\u0e1e) \u0e41\u0e25\u0e30\u0e22\u0e32 PEP (\u0e40\u0e1b\u0e47\u0e1b)<\/a><\/p>\n<p>\u21aa\ufe0e <a href=\"https:\/\/pharmacy.mahidol.ac.th\/dic\/knowledge_full.php?id=81\">\u0e01\u0e32\u0e23\u0e1b\u0e49\u0e2d\u0e07\u0e01\u0e31\u0e19\u0e40\u0e2d\u0e0a\u0e44\u0e2d\u0e27\u0e35\u0e14\u0e49\u0e27\u0e22 PrEP &amp; PEP \u0e15\u0e48\u0e32\u0e07\u0e01\u0e31\u0e19\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e44\u0e23<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0e40\u0e0a\u0e37\u0e48\u0e2d\u0e27\u0e48\u0e32\u0e2b\u0e25\u0e32\u0e22\u0e04\u0e19\u0e04\u0e07\u0e40\u0e04\u0e22\u0e44\u0e14\u0e49\u0e22\u0e34\u0e19\u0e02\u0e49\u0e2d\u0e21\u0e39\u0e25\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e01\u0e31\u0e1a \u0e22\u0e32\u0e17\u0e35\u0e48\u0e43\u0e0a\u0e49\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e17\u0e32\u0e19\u0e1b\u0e49\u0e2d\u0e07\u0e01\u0e31\u0e19\u0e44\u0e27\u0e23\u0e31\u0e2a\u0e40\u0e2d\u0e0a\u0e44\u0e2d\u0e27\u0e35\u0e21\u0e32\u0e01\u0e48\u0e2d\u0e19 \u0e17\u0e31\u0e49\u0e07 PrEP \u0e41\u0e25\u0e30 PEP \u0e41\u0e15\u0e48\u0e01\u0e47\u0e22\u0e31\u0e07\u0e21\u0e35\u0e04\u0e27\u0e32\u0e21<\/p>\n","protected":false},"author":3,"featured_media":19316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[568,567],"tags":[619,621,633,1042,622,1408,639],"class_list":["post-19311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pep-en","category-prep-en","tag-hiv-infection","tag-hiv-prevention","tag-hiv-transmission","tag-pep-en","tag-prep","tag-prep-vs-pep","tag-stis"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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